Anaplastic large cell lymphoma, ALK-positive

Definition

A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm characterised by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement.

Inclusions

• Anaplastic large cell lymphoma, CD30-positive

Also indexed as

Nearby in Mature T-cell lymphoma, specified types, nodal or systemic

• 2A90.0T-cell prolymphocytic leukaemia
• 2A90.1T-cell large granular lymphocytic leukaemia
• 2A90.2Chronic lymphoproliferative disorders of NK-cells
• 2A90.3Aggressive NK cell leukaemia
• 2A90.4Systemic Epstein-Barr Virus-positive T-cell lymphoma of childhood
• 2A90.5Adult T-cell lymphoma or leukaemia, human T-cell lymphotropic virus type 1-associated
• 2A90.6Extranodal NK/T-cell lymphoma, nasal type
• 2A90.7Enteropathy associated T-cell lymphoma