Hepatosplenic T-cell lymphoma

Definition

An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterised by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.

Also indexed as

Nearby in Mature T-cell lymphoma, specified types, nodal or systemic

• 2A90.0T-cell prolymphocytic leukaemia
• 2A90.1T-cell large granular lymphocytic leukaemia
• 2A90.2Chronic lymphoproliferative disorders of NK-cells
• 2A90.3Aggressive NK cell leukaemia
• 2A90.4Systemic Epstein-Barr Virus-positive T-cell lymphoma of childhood
• 2A90.5Adult T-cell lymphoma or leukaemia, human T-cell lymphotropic virus type 1-associated
• 2A90.6Extranodal NK/T-cell lymphoma, nasal type
• 2A90.7Enteropathy associated T-cell lymphoma