Immunodeficiency-associated lymphoproliferative disorders

Definition

Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV-negative lymphomas of predominantly B-cell or less often T-cell type. In other immunodeficiency-associated lymphoproliferative disorders, association with EBV is less pronounced.

Inclusions

• PTLD - [Post transplant lymphoproliferative disorder]

6 subordinate codes

• 2B32.0Post-transplant lymphoproliferative disorder, early lesion
• 2B32.1Reactive plasmacytic hyperplasia
• 2B32.2Post-transplant lymphoproliferative disorder, Infectious mononucleosis-like
• 2B32.3Polymorphic post-transplant lymphoproliferative disorder
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified

Nearby in Neoplasms of haematopoietic or lymphoid tissues

• 2A20-2A2ZMyeloproliferative neoplasms
• 2A30-2A3ZMyelodysplastic syndromes
• 2A40-2A4ZMyelodysplastic and myeloproliferative neoplasms
• 2A50-2A5ZMyeloid or lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
• 2A60Acute myeloid leukaemias and related precursor neoplasms
• 2A61Acute leukaemias of ambiguous lineage
• 2A70-2A7ZPrecursor lymphoid neoplasms
• 2A80-2A8ZMature B-cell neoplasms