Myeloid proliferation associated with Down syndrome

Definition

Myeloid neoplasms occurring in individuals with Down syndrome. There is an increased risk of acute leukaemias in both children and adults with Down syndrome. In particular, the incidence of acute myeloid leukaemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukaemia, and is associated with GATA1 gene mutation. This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.

4 subordinate codes

• 2A60.40Transient abnormal myelopoiesis
• 2A60.41Myeloid leukaemia associated with Down syndrome
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified

Nearby in Acute myeloid leukaemias and related precursor neoplasms

• 2A60.0Acute myeloid leukaemia with recurrent genetic abnormalities
• 2A60.1Acute myeloid leukaemia with myelodysplasia-related changes
• 2A60.2Therapy-related myeloid neoplasms
• 2A60.3Acute myeloid leukaemia, not elsewhere classified by criteria of other types
• 2A60.5Blastic plasmacytoid dendritic cell neoplasm
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified