Myelodysplastic syndromes

Definition

Clonal hematopoietic disorders characterised by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20% in marrow and blood, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukaemia.

Exclusions

• Drug-induced aplastic anaemia (3A70.10)
• Therapy-related myeloid neoplasms (2A60.2)

11 subordinate codes

• 2A30Refractory anaemia
• 2A31Refractory neutropaenia
• 2A32Refractory thrombocytopenia
• 2A33Refractory anaemia with ring sideroblasts
• 2A34Refractory cytopenia with multi-lineage dysplasia
• 2A35Refractory anaemia with excess of blasts
• 2A36Myelodysplastic syndrome with isolated del(5q)
• 2A37Myelodysplastic syndrome, unclassifiable
• 2A38Refractory cytopenia of childhood
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified

Nearby in Neoplasms of haematopoietic or lymphoid tissues

• 2A20-2A2ZMyeloproliferative neoplasms
• 2A40-2A4ZMyelodysplastic and myeloproliferative neoplasms
• 2A50-2A5ZMyeloid or lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
• 2A60Acute myeloid leukaemias and related precursor neoplasms
• 2A61Acute leukaemias of ambiguous lineage
• 2A70-2A7ZPrecursor lymphoid neoplasms
• 2A80-2A8ZMature B-cell neoplasms
• 2A90-2B2ZMature T-cell or NK-cell neoplasms