Myeloid or lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1

Definition

A group of rare myeloid or lymphoid neoplasms characterised by rearrangement of the platelet-derived growth factor receptor alpha (PDGFRA), platelet-derived growth factor receptor beta (PDGFRB), and fibroblast growth factor receptor-1 (FGFR1) genes, resulting in the formation of fusion transcripts and aberrant tyrosine kinase activity. Eosinophilia is a characteristic finding but it is not always present.

4 subordinate codes

• 2A50Myeloid or lymphoid neoplasm associated with PDGFRA rearrangement
• 2A51Myeloid neoplasm associated with PDGFRB rearrangement
• 2A52Myeloid or lymphoid neoplasms with FGFR1 abnormalities
• 4B4ZDiseases of the immune system, unspecified

Nearby in Neoplasms of haematopoietic or lymphoid tissues

• 2A20-2A2ZMyeloproliferative neoplasms
• 2A30-2A3ZMyelodysplastic syndromes
• 2A40-2A4ZMyelodysplastic and myeloproliferative neoplasms
• 2A60Acute myeloid leukaemias and related precursor neoplasms
• 2A61Acute leukaemias of ambiguous lineage
• 2A70-2A7ZPrecursor lymphoid neoplasms
• 2A80-2A8ZMature B-cell neoplasms
• 2A90-2B2ZMature T-cell or NK-cell neoplasms