Plasma cell neoplasms

Definition

Plasma cell neoplasms are a group of disorders characterized by the monoclonal expansion of terminally differentiated B cells (plasma cells) that produce monoclonal immunoglobulins, known as M proteins or paraproteins. Key types include plasma cell myeloma (multiple myeloma), plasmacytoma, and neoplasms associated with paraneoplastic syndromes like POEMS syndrome.

8 subordinate codes

• 2A83.0Monoclonal gammopathy of undetermined significance
• 2A83.1Plasma cell myeloma
• 2A83.2Solitary plasmacytoma
• 2A83.3Extraosseous plasmacytoma
• 2A83.4Plasma cell leukaemia
• 2A83.5Monoclonal immunoglobulin deposition disease
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified

Nearby in Mature B-cell neoplasms

• 2A80Follicular lymphoma
• 2A81Diffuse large B-cell lymphomas
• 2A82Mature B-cell neoplasm with leukaemic behaviour
• 2A84Heavy chain diseases or malignant immunoproliferative diseases
• 2A85Other specified mature B-cell neoplasms or lymphoma
• 2A86B-cell lymphoma, mixed features
• 4B4ZDiseases of the immune system, unspecified