Chronic myelomonocytic leukaemia

Definition

A myelodysplastic/myeloproliferative neoplasm which is characterised by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL1 fusion gene, fewer than 20 percent blasts in the bone marrow and blood, often myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement.

Inclusions

• Chronic monocytic leukaemia

Exclusions

• Myeloid neoplasm associated with PDGFRB rearrangement (2A51)
• Myeloid or lymphoid neoplasm associated with PDGFRA rearrangement (2A50)

Also indexed as

Nearby in Myelodysplastic and myeloproliferative neoplasms

• 2A41Atypical chronic myeloid leukaemia, BCR-ABL1-negative
• 2A42Juvenile myelomonocytic leukaemia
• 2A43Refractory anaemia with ring sideroblasts associated with marked thrombocytosis
• 2A44Myeloproliferative and myelodysplastic disease, unclassifiable
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified