Diabetic cardiomyopathy
Definition
Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvar disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia. It is initially characterised by myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, progressing to systolic dysfunction and heart failure. Additional information. The development and progression of diabetic cardiomyopathy has been linked to impaired cardiac insulin metabolic signaling, increases in oxidative stress, reduced nitric oxide bioavailability, collagen-based cardiomyocyte and extracellular matrix stiffness, impaired mitochondrial and cardiomyocyte calcium handling, inflammation, renin–angiotensin–aldosterone system activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular dysfunction, and a myriad of cardiac metabolic abnormalities.
Coding note
Always assign an additional code for diabetes mellitus.
Also indexed as
Nearby in Cardiomyopathy
BC43.0Dilated cardiomyopathyBC43.1Hypertrophic cardiomyopathyBC43.2Restrictive cardiomyopathyBC43.3Endocardial fibroelastosisBC43.4Cardiomyopathy due to drugs or other external agentsBC43.5Stress-induced cardiomyopathyBC43.6Arrhythmogenic ventricular cardiomyopathy4B4YOther specified diseases of the immune system