8C62
category
Lambert-Eaton syndrome
Definition
Lambert-Eaton myasthenic syndrome, 20 times as rare as acetylcholine receptor positive myasthenia gravis with a prevalence of 3.42 per million, is an immune-mediated disease of the neuromuscular junction. Clinically the disease is characterised by proximal weakness of the legs. In most patients, the weakness extends to other muscles including the oculobulbar ones. Autonomic symptoms (dry mouth, erectile dysfunction, constipation) are frequent. Tendon reflexes are reduced. Repetitive nerve stimulation shows low compound muscle action potentials, decrement > 10% at low frequency and increment > 100% after maximum voluntary contraction at high frequency.
Also indexed as
Eaton-Lambert syndromeLEMS - [Lambert-Eaton myasthenic syndrome]Lambert-Eaton myasthenic syndromeLambert-Eaton myasthenic syndrome, antibody positiveLambert-Eaton syndromeLambert-Eaton syndrome, antibody positiveLambert-Eaton syndrome, autoimmune-acquiredLambert-Eaton syndrome, malignancy associationMyasthenic-Myopathic syndrome of Lambert-EatonParaneoplastic Lambert Eaton myasthenic syndromeParaneoplastic Lambert Eaton syndromeSOX-associated Lambert-Eaton myasthenic syndromeVoltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome