5C64.10
category
Iron overload diseases
Definition
Iron overload is the accumulation of excess iron in body tissues. Iron overload usually occurs as a result of a genetic predisposition to absorb and store iron in excess amounts, the most common form of which is hereditary hemochromatosis. Iron overload can also occur as a complication of other hematologic disorders that require chronic transfusion therapy, repeated injections of parenteral iron, or excessive iron ingestion. Excessive iron stores usually accumulate in the reticuloendothelial tissues and cause little damage (“hemosiderosis”). If overload continues, iron eventually begins to accumulate in tissues such as hepatic parenchyma, pancreas, heart and synovium, causing hemochromatosis.
Also indexed as
Acquired hemochromatosisAcquired iron overloadAfrican iron overloadArthropathy in haemochromatosisAtypical pantothenate kinase associated neurodegenerationAutosomal dominant hereditary haemochromatosisAutosomal recessive spastic paraplegia type 35BPAN - [Beta-Propeller protein-associated neurodegeneration]Bantu haemosiderosisBeta-Propeller protein-associated neurodegenerationC282Y/C282Y haemochromatosisCOASY Protein-Associated NeurodegenerationClassic haemochromatosisClassic pantothenate kinase associated neurodegenerationCoPAN - [COASY Protein-Associated Neurodegeneration]Dietary haemosiderosisFAHN - [Fatty Acid Hydroxylase-Associated Neurodegeneration]Fatty Acid Hydroxylase-Associated NeurodegenerationFerroportin diseaseHARP - [hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration]HFE-related hereditary haemochromatosis, Type 1HSS - [Hallervorden-Spatz-Syndrome] (deprecated)Haemochromatosis due to defect in ferroportinHallervorden-Spatz disease (deprecated)Hemojuvelin-related haemochromatosisHepcidin-related haemochromatosisHereditary haemochromatosisINAD - [Infantile neuroaxonal dystrophy]Infantile neuroaxonal dystrophyIron overload diseasesIron overload in sub-Saharan AfricaJuvenile hereditary haemochromatosis, Type 2Juvenile hereditary haemochromatosis, Type 2AJuvenile hereditary haemochromatosis, Type 2BKRS - [Kufor-Rakeb syndrome]Kufor-Rakeb syndromeMPAN - [Mitochondrial Membrane Protein-Associated Neurodegeneration]Mitochondrial Membrane Protein-Associated NeurodegenerationNBIA - [Neurodegeneration with brain iron accumulation]NBIA 2 PLA2G6 mutationNBIA1 - [Neurodegeneration with brain iron accumulation type 1]NBIA1 - [Neurodegeneration with brain iron accumulation type 1] atypical formNBIA1 - [Neurodegeneration with brain iron accumulation type 1] classic formNBIA2 - [Neurodegeneration with brain iron accumulation type 2]NBIA4 - [Neurodegeneration with Brain Iron Accumulation type 4]NBIA5 - [Neurodegeneration with brain iron accumulation type 5]Neonatal haemochromatosisNeurodegeneration with Brain Iron Accumulation type 4Neurodegeneration with brain iron accumulationNeurodegeneration with brain iron accumulation due to C19orf12 mutationNeurodegeneration with brain iron accumulation type 1Neurodegeneration with brain iron accumulation type 1, atypical formNeurodegeneration with brain iron accumulation type 1, classic formNeurodegeneration with brain iron accumulation type 2Non-HFE-related hereditary haemochromatosis, Type 3Non-HFE-related hereditary haemochromatosis, Type 4PANK2 gene mutation-associated neurodegenerationPARK14 - [Parkinson disease 14]PARK9 - [Parkinson Disease Type 9]PKAN - [Pantothenate-kinase-associated neurodegeneration]PKAN - [Pantothenate-kinase-associated neurodegeneration] atypical formPKAN - [Pantothenate-kinase-associated neurodegeneration] classic formPLA2G6-associated neurodegenerationPLAN - [PLA2G6-Associated Neurodegeneration]Pantothenate-kinase-associated neurodegenerationParkinson Disease Type 9SPG35 - [Spastic Paraplegia 35]Secondary iron overloadSeitelberger disease (deprecated)Spastic Paraplegia 35TFR2-related haemochromatosishemosiderosisidiopathic haemosiderosisneurodegeneration with brain iron accumulation type 5pigmentary pallidal atrophypigmentary pallidal degenerationprogressive pigmentary pallidal degeneration