Low affinity haemoglobin

Definition

A disease caused by determinants arising after birth, in the antenatal period or by genetically inherited factors leading to low oxygen affinity haemoglobin. This disease is characterised by abnormalities in the globin chains that alter the affinity of the haemoglobin molecule for oxygen, affecting the normal loading of oxygen in the lungs and delivery of oxygen to the tissues. This disease may present with fatigue, muscle weakness, loss of appetite, weight loss, diarrhoea, nausea, fast heartbeat or numbness in extremities.

Also indexed as

Nearby in Sickle cell disorders or other haemoglobinopathies

• 3A51.0Sickle cell trait
• 3A51.1Sickle cell disease without crisis
• 3A51.2Sickle cell disease with crisis
• 3A51.3Compound heterozygous sickling disorders without crisis
• 3A51.4Compound heterozygous sickling disorders with crisis
• 3A51.5Haemoglobin C disease
• 3A51.6Haemoglobin D disease
• 3A51.7High affinity haemoglobin