Autoimmune haemolytic anaemia, cold type

Definition

Cold autoimmune haemolytic anaemia comprises two types of autoimmune haemolytic anaemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold haemoglobinuria (PCH). CAD is more common in people over the age of 55 years, while PCH typically presents in young children. CAD is caused by IgM autoantibodies while PCH is caused by an IgG immunoglobulin.

Inclusions

• Cold haemagglutinin disease

Exclusions

• Haemolytic disease of fetus or newborn (KA84)
• Immune thrombocytopenic purpura (3B64.10)

Also indexed as

Nearby in Acquired haemolytic anaemia, immune

• 3A20.0Autoimmune haemolytic anaemia, warm type
• 3A20.2Autoimmune haemolytic anaemia, mixed type, cold and warm
• 3A20.3Paroxysmal cold haemoglobinuria
• 3A20.4Alloimmune haemolytic anaemia
• 3A20.5Evans syndrome
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified