Diffuse mesangial sclerosis

Definition

Diffuse mesangial sclerosis is a histological appearance which is characterised by diffuse thickening of basement membrane and massive enlargement of mesangial areas leading to contraction and sclerosis of the glomerular capillary tuft. It may be seen in children with early onset steroid resistant nephrotic syndrome due to a variety of genetic abnormalities, either as an isolated renal disease or as part of a multi-organ syndrome.

Also indexed as

Nearby in Clinical findings in specimens from the urinary system

• MF81Fibronectin glomerulopathy
• MF82Lipoprotein glomerulopathy
• MF83Diabetic glomerular changes
• MF84Pauci-immune proliferative glomerulonephritis
• MF85Anti-glomerular basement membrane antibody mediated disease
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified