GB90.4A
category
Nephrogenic diabetes insipidus
Definition
Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatraemic dehydration after birth that may cause neurological sequelae.
Exclusions
- Central diabetes insipidus
(5A61.5)
Also indexed as
ADH - [antidiuretic-hormone] resistant diabetes insipidusAQP2 mutationAcquired nephrogenic diabetes insipidus due to causes classified elsewhereNDI - [nephrogenic diabetes insipidus]Nephrogenic Diabetes Insipidus associated with familial or genetic disorders elsewhere classifiedNephrogenic diabetes insipidusNephrogenic diabetes insipidus - intracranial calcificationVasopressin-resistant hyposthenuriaVasopressin-unresponsiveness hyposthenuriaX-linked AVPR2 mutationadiuretin-resistant diabetes insipidusantidiuretic-hormone-resistant diabetes insipiduscongenital nephrogenic diabetes insipidusdiabetes tenuifluusfamilial nephrogenic diabetesfamilial nephrogenic diabetes insipidushereditary nephrogenic diabetes insipidusprimary nephrogenic diabetes insipidusrenal diabetes insipidusvasopressin-resistant diabetes insipidus