Malignant neoplasms of liver or intrahepatic bile ducts

Definition

The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish.

Exclusions

• Malignant neoplasm of biliary tract NOS (2C17)
• Secondary malignant neoplasm of liver (2D80)

2 subordinate codes

• 2C12.0Malignant neoplasm of liver
• 2C12.1Malignant neoplasm of intrahepatic bile ducts

Also indexed as

Nearby in Malignant neoplasms of digestive organs

• 2B70Malignant neoplasms of oesophagus
• 2B71Malignant neoplasms of oesophagogastric junction
• 2B72Malignant neoplasms of stomach
• 2B80-2C0ZMalignant neoplasms of intestine
• 2C10Malignant neoplasm of pancreas
• 2C11Malignant neoplasms of other or ill-defined digestive organs
• 2C13Malignant neoplasms of gallbladder
• 2C14Malignant neoplasms of proximal biliary tract, cystic duct