08Diseases of the nervous system
Diseases of neuromuscular junction or muscle
Primary disorders of muscles
8C71Myotonic disorders
8C71.4
category
Neuromyotonia
Definition Neuromyotonia or Isaac's syndrome is an immune-mediated peripheral nerve disorder characterised by continuous muscle fibre activity at rest resulting in muscle stiffness, cramps, myokymia, and pseudomyotonia.
Also indexed as
Isaacs neuromyotonia Isaacs syndrome Isaacs-Mertens syndrome Neuromyotonia continuous muscle fibre activity
Nearby in Myotonic disorders
International Classification of Diseases, Eleventh Revision (ICD-11), World Health Organization (WHO) 2019/2021, https://icd.who.int/browse11. Licensed under Creative Commons Attribution-NoDerivatives 3.0 IGO (CC BY-ND 3.0 IGO).
Release 2026-01.
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This page reproduces WHO classification content for reference. It is not
medical advice and must not be used to diagnose or treat. For coding
decisions, consult the official release and your national coding guidelines.
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