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Chapters ENES DE

08Diseases of the nervous system
Multiple sclerosis or other white matter disorders

8A45 category

Secondary white matter disorders

7 subordinate codes

8A45.0White matter disorders due to infections
8A45.1White matter disorders due to toxicity
8A45.2White matter disorders due to vascular abnormality or ischemia
8A45.3White matter disorders due to nutritional deficiency
8A45.4White matter disorders due to certain specified systemic disease
4B4YOther specified diseases of the immune system
4B4ZDiseases of the immune system, unspecified

Nearby in Multiple sclerosis or other white matter disorders

8A40Multiple sclerosis
8A41Isolated demyelinating syndromes of the central nervous system
8A42Acute disseminated encephalomyelitis
8A43Neuromyelitis optica
8A44Leukodystrophies
8A46Central demyelination of corpus callosum
4B4YOther specified diseases of the immune system
4B4ZDiseases of the immune system, unspecified

Previous8A44 — Leukodystrophies Next8A46 — Central demyelination of corpus callosum

Browse ICD-11

01Certain infectious or parasitic diseases
02Neoplasms
03Diseases of the blood or blood-forming organs
04Diseases of the immune system
05Endocrine, nutritional or metabolic diseases
06Mental, behavioural or neurodevelopmental disorders
07Sleep-wake disorders
08Diseases of the nervous system
09Diseases of the visual system
10Diseases of the ear or mastoid process
11Diseases of the circulatory system
12Diseases of the respiratory system
13Diseases of the digestive system
14Diseases of the skin
15Diseases of the musculoskeletal system or connective tissue
16Diseases of the genitourinary system
17Conditions related to sexual health
18Pregnancy, childbirth or the puerperium
19Certain conditions originating in the perinatal period
20Developmental anomalies
21Symptoms, signs or clinical findings, not elsewhere classified
22Injury, poisoning or certain other consequences of external causes
23External causes of morbidity or mortality
24Factors influencing health status or contact with health services
25Codes for special purposes
26Supplementary Chapter Traditional Medicine Conditions
VSupplementary section for functioning assessment
XExtension Codes
8A00-8A0ZMovement disorders
8A20-8A2ZDisorders with neurocognitive impairment as a major feature
8A40-8A4ZMultiple sclerosis or other white matter disorders
8A60-8A6ZEpilepsy or seizures
8A80-8A8ZHeadache disorders
8B00-8B2ZCerebrovascular diseases
8B40-8B4ZSpinal cord disorders excluding trauma
8B60-8B6ZMotor neuron diseases or related disorders
8B80-8C4ZDisorders of nerve root, plexus or peripheral nerves
13 more
8A40Multiple sclerosis
8A41Isolated demyelinating syndromes of the central nervous system
8A42Acute disseminated encephalomyelitis
8A43Neuromyelitis optica
8A44Leukodystrophies
8A45Secondary white matter disorders
8A46Central demyelination of corpus callosum
4B4YOther specified diseases of the immune system
4B4ZDiseases of the immune system, unspecified
8A45.0White matter disorders due to infections
8A45.1White matter disorders due to toxicity
8A45.2White matter disorders due to vascular abnormality or ischemia
8A45.3White matter disorders due to nutritional deficiency
8A45.4White matter disorders due to certain specified systemic disease
4B4YOther specified diseases of the immune system
4B4ZDiseases of the immune system, unspecified

International Classification of Diseases, Eleventh Revision (ICD-11), World Health Organization (WHO) 2019/2021, https://icd.who.int/browse11. Licensed under Creative Commons Attribution-NoDerivatives 3.0 IGO (CC BY-ND 3.0 IGO).

Release 2026-01. View this entity in the official WHO ICD-11 browser.

This page reproduces WHO classification content for reference. It is not medical advice and must not be used to diagnose or treat. For coding decisions, consult the official release and your national coding guidelines.

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