Kleine-Levin syndrome

Definition

Kleine-Levin syndrome is characterised by recurrent episodes of severe sleepiness in association with cognitive, psychiatric, and behavioural disturbances. A typical episode lasts a median of 10 days (range 2.5–80 days), with rare episodes lasting several weeks to months. During episodes, patients may sleep as long as 16 to 20 hours per day, waking or getting up only to eat and void. When awake during episodes, most patients are exhausted, apathetic, confused, and slow in speaking and answering. Hyperphagia, hypersexuality, childish behaviour, depression, anxiety, hallucinations and delusions are often observed during the episodes. Patients are normal between episodes with regard to sleep, cognition, mood, and eating. Rarely, Kleine Levin syndrome may occur exclusively during menstrual periods.

Inclusions

• recurrent hypersomnolence

Also indexed as

Nearby in Hypersomnolence disorders

• 7A20Narcolepsy
• 7A21Idiopathic hypersomnia
• 7A23Hypersomnia due to a medical condition
• 7A24Hypersomnia due to a medication or substance
• 7A25Hypersomnia associated with a mental disorder
• 7A26Insufficient sleep syndrome
• 4B4YOther specified diseases of the immune system
• 4B4ZDiseases of the immune system, unspecified