3B65
category
Thrombotic microangiopathy, not elsewhere classified
Definition
Thrombotic microangiopathies are microvascular occlusive disorders characterised by systemic or intrarenal aggregation of platelets, thrombocytopenia, and mechanical injury to erythrocytes. Thrombotic thrombocytopenic purpura (TTP) and haemolytic–uremic syndrome (HUS) represent a spectrum of thrombotic microangiopathies. In TTP, systemic microvascular aggregation of platelets causes ischemia in the brain and other organs. In HUS, platelet–fibrin thrombi predominantly occlude the renal circulation.
Also indexed as
Acute intravascular thrombi microangiopathyAcute intravascular thrombotic microangiopathyChronic intravascular thrombi microangiopathyChronic intravascular thrombotic microangiopathyThrombotic microangiopathy, not elsewhere classified